1Dr. Hashmatullah Khan, 2Dr Noor Asad, 3Dr. Muhammad Nazir, 4Dr. Tajdar Ali, 5Dr Iftikhar Ahmed, 6Dr. Wiqar Ahmad
1Assistant Professor Gastro Leady Reading Hospital Peshawar.
2House Officer, Qazi Hussain Ahmed Medical Complex
3Assistant Professor Gastroenterology, Northwest General hospital and R.C Peshawar.
4Senior Registrar, Northwest General Hospital and Research Centre Peshawar
5Registrar Gastroenterology Northwest General Hospital and Research Centre, Peshawar
6Senior Registrar, Northwest General Hospital and Research Centre Peshawar
Abstract
Background: Peptic Ulcer Disease (PUD) is one of the most common gastrointestinal disorders characterized by sores or ulcers in the lining of stomach and first part of small intestine. In addition, the factors causing PUD recurrence to remain unresolved in some cases; early diagnosis of these risk factors is therefore clinically meaningful. This cross-sectional study aimed to determine various risk factors for PUD recurrence in patients managed at the tertiary care hospital, (NWGH) in Peshawar.
Objective: To determine the risk factors for recurrences of Peptic ulcer disease at a tertiary care hospital in Peshawar.
Aim: To determine the risk factors for recurrences of Peptic ulcer disease at a tertiary care hospital in Peshawar
Method: This retrospective cohort study was carried out at the tertiary care hospital in Peshawar. A total of patients diagnosed with PUD and treated from January 2018-December 2020. This information was extracted retrospectively from patient records, including demographics and clinical characteristics relevant to potential risk factors. All person-years at risk were divided intothersee exposure strata- H pylori infection, use of NSAIDs; and all other referred to as normal-with homogeneous consumption distribution of coffee containing varying Social Science Citation Union (HIC/SKI) classified used as the reference. We then used multivariate logistic regression to determine the predictors of PUD recurrence.
Results: The study included 500 patients with a mean age of 52 years; and sixty percent were male. Yearly rates of PUD recurrence were 35%. H pylori infection (odds ratio [OR] 2.8, 95% confidence interval [CI] )1.9-4.1), regular NSAID use (OR 2.5, CI = ), smoking (OR HQ: *****) and older age (<0. Propensity analysis demonstrated a higher incidence of recurrence for multiperiod risk patients.
Conclusion: Identifying and controlling the major risk factors of PUD recurrence is crucial; they include infection with Helicobacter pylori, use of NSAID, & smoking habit. The high lidocaine intubation failure rate at this centre emphasizes that elimination of contributing factors is key to decreasing recurrences and improving outcomes in a tertiary care setting. Future studies are recommended for examining other risk factors as well, making complete prevention and management protocols.
Keywords: Peptic Ulcer Disease, Older Adults, Recurrence, Risk Factors, Helicobacter pylori, NSAIDs, Smoking, Tertiary Care Hospital, Peshawar.