1Ali Hammad, 2Fazal Mohammad, 3Nadia Niaz, 4Hamdan Yunus, 5Asia Asim
1UHS, Lahore
2Baluchistan Institute of Nephro Urology Quetta
3Baluchistan Institute of Nephro Urology Quetta
4PIMS
5CPSP, Karachi
Correspondence: Ali Hammad, UHS, Lahore
| Abstract Background: Renal side effects are a significant concern with the use of commonly prescribed drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, and chemotherapeutic agents. These medications, while effective for their intended purposes, have been associated with various forms of nephrotoxicity, leading to acute kidney injury and chronic kidney disease. Understanding these renal complications and developing strategies for their prevention and management is crucial to optimizing patient outcomes. Aim: This study aimed to investigate the renal side effects associated with the use of NSAIDs, antibiotics, and chemotherapeutic agents and to identify effective strategies for the prevention and management of these adverse effects. Methods: A retrospective cohort study was conducted from June 2023 to May 2024, involving 90 participants who had been prescribed NSAIDs, antibiotics, or chemotherapeutic agents. Participants were selected based on their exposure to these medications and the subsequent development of renal complications. Data were collected from medical records, including patient demographics, drug type and dosage, renal function tests, and outcomes. Statistical analyses were performed to identify risk factors associated with renal side effects and evaluate the efficacy of implemented management strategies. Results: The study found that 28% of participants experienced significant renal side effects, with acute kidney injury being the most common complication. NSAIDs were associated with a higher incidence of renal impairment compared to antibiotics and chemotherapeutic agents. The implementation of renal protective strategies, including dose adjustments and concurrent use of nephroprotective agents, was effective in reducing the severity of renal complications. Early identification and intervention were crucial in preventing the progression to chronic kidney disease. Conclusion: This study highlighted the substantial risk of renal side effects associated with NSAIDs, antibiotics, and chemotherapeutic agents. The findings underscore the importance of careful drug selection, dosing, and monitoring to prevent and manage nephrotoxicity. Clinicians should be vigilant in identifying at-risk patients and employing protective strategies to mitigate renal damage, ultimately improving patient outcomes. Keywords: NSAIDs, antibiotics, chemotherapeutic agents, nephrotoxicity, renal side effects, acute kidney injury, chronic kidney disease, nephroprotection, drug safety. |