1 Aziz ur Rahman, 2 Dr Mohammad Kamran, 3 Asad Khalil, 4 Vagma Rahman, 5 Sajjad Ahmad
1Urology Department, Northwest General Hospital Peshawar
2Anaesthesia Department, NWGH
3Dept of Medicine Lady Reading Hospital, Peshawar
4 Department of Surgery, NWGH Peshawar
5Urology Department, NWGH Peshawar
ABSTRACT:
Background: The urinary microbiome plays a crucial role in the development and management of urological conditions, including urinary tract infections (UTIs) and bladder cancer. Understanding the interactions between microbial communities and the host can provide insights into disease mechanisms and potential therapeutic targets.
Aim: This study aimed to investigate the influence of the urinary microbiome on the development and management of urological conditions, particularly UTIs and bladder cancer. Methods: A total of 120 participants were recruited for this study, conducted from March 2023 to February 2024. The study population included patients diagnosed with UTIs, bladder cancer, and healthy controls. Urine samples were collected and analyzed using 16S rRNA gene sequencing to profile the microbiome. Clinical data were also collected to assess correlations between microbial composition and disease characteristics.
Results: The study found significant differences in the urinary microbiome between patients with UTIs, bladder cancer, and healthy controls. Patients with UTIs showed an increased abundance of pathogenic bacteria, while those with bladder cancer had a distinct microbial profile compared to healthy controls. Specific microbial taxa were associated with disease severity and treatment outcomes. The findings suggested potential microbial biomarkers for diagnosing and managing urological conditions.
Conclusion: The urinary microbiome significantly influenced the development and management of UTIs and bladder cancer.
Identifying specific microbial profiles associated with these conditions could enhance diagnostic accuracy and inform personalized treatment strategies. Further research is needed to explore the therapeutic potential of modulating the urinary microbiome in urological diseases. Keywords: Urinary microbiome, urinary tract infections, bladder cancer, 16S rRNA gene sequencing, microbial biomarkers, urological conditions.