1 Ali Raza, 2Fazal Mohammad, 3Nadia Niaz, 4Mobeen Ali, 5Kamran Safdar
1PIMS
2Baluchistan Institute of Nephro Urology Quetta
3Balochistan Institute of Nephro Urology Quetta
4PIMS
5PIMS
Correspondence: Ali Raz, PIMS
Abstract
Background: Kidney transplantation has evolved significantly over the past few decades, driven by advancements in donor selection, immunosuppression strategies, and long-term recipient management. These developments have contributed to improved outcomes, reduced complications, and extended graft survival, addressing the critical need for effective treatment in end-stage renal disease patients.
Aim: This study aimed to evaluate the impact of recent advancements in kidney transplantation on donor selection criteria, immunosuppressive regimens, and the long-term outcomes for transplant recipients.
Methods: A retrospective analysis was conducted from June 2023 to May 2024, involving a study population of 90 kidney transplant recipients. Data were collected on donor selection processes, immunosuppressive therapies used, and long-term outcomes, including graft survival and recipient health. The study assessed the correlation between these variables and patient outcomes using statistical methods.
Results: The study found that advancements in donor selection, particularly the use of expanded criteria donors, significantly increased the donor pool without compromising graft survival. Innovations in immunosuppression, including the use of newer agents and personalized regimens, were associated with a decrease in acute rejection rates and long-term complications. Overall, the long-term outcomes for recipients showed marked improvement, with a higher percentage of patients achieving sustained graft function and improved quality of life.
Conclusion: The advancements in kidney transplantation have led to significant improvements in both short-term and long-term outcomes for recipients. Enhanced donor selection criteria and modern immunosuppressive therapies have expanded the availability of organs and reduced the incidence of graft rejection, ultimately contributing to better patient survival and quality of life.
Keywords: Kidney transplantation, donor selection, immunosuppression, graft survival, long-term outcomes, end-stage renal disease.