JANUARY 2024
Investigate the connection between excess body weight and the onset of pancreatitis, focusing on the mechanisms by which additional adipose tissue may cause pancreatic inflammation
1Dr. Waseem Ahmed Shah Kazmi, 2Sadaf Khalid, 3Mohib Ali, 4Ali Raza, 5 Dr. Waqar Azeem , 6Dr. Faran Hamid
1Department of Neurosciences, King’s College Hospital, London
2Surgical Associate, Doctor’s Hospital and Medical Center, Punjab, Pakistan
3PIMS
4PIMS
5Department of Pathology Isra University Hyderabad Pakistan
6Senior Registrar, Department of General Surgery, RLKU Medical & Dental College, Hameed Latif Teaching Hospital, Lahore
ABSTRACT
Background: Pancreatitis is the condition characterized by inflammation of pancreas, often related through significant morbidity. Excess body weight was proposed as the dangerous aspect for progress of pancreatitis, yet specific mechanisms through which adipose tissue contributes to pancreatic inflammation remain unclear.
Aim: This study aimed to explore the relationship among excess body weight and expansion of pancreatitis, focusing on mechanisms through which excess adipose tissue may lead to pancreatic inflammation.
Methods: A retrospective cohort study was led from January 2023 to January 2024. The study population consisted of 120 individuals diagnosed with pancreatitis, with data collected from medical records. Patients were categorized based on their body mass index (BMI) into normal weight, overweight, and obese groups. Clinical data, including laboratory results and imaging studies, were analyzed to assess the correlation between body weight and severity of pancreatitis. Additionally, markers of inflammation and adipokines were measured to investigate potential mechanisms of pancreatic inflammation.
Results: The study found a significant correlation among excess body weight and incidence of pancreatitis. Obese individuals were more likely to progress severe forms of pancreatitis compared to those with normal weight (p < 0.05). Elevated levels of pro-inflammatory markers, like C-reactive protein (CRP) and interleukin-6 (IL-6), were observed in overweight and obese patients, suggesting a link between adipose tissue and systemic inflammation. Furthermore, increased levels of adipokines, including leptin and adiponectin, were noted in these patients, indicating a potential mechanistic pathway for adipose tissue-induced pancreatic inflammation.
Conclusion: Excess body weight was related through an enlarged danger and severity of pancreatitis. The study highlighted role of systemic inflammation and adipokines in mediating pancreatic inflammation in individuals with excess adipose tissue. Those results underscore significance of weight management in preventing pancreatitis and suggest potential therapeutic targets for mitigating pancreatic inflammation in obese patients.
Keywords: Pancreatitis, Excess body weight, Adipose tissue, Inflammation, Adipokines, Obesity.