ABSTRACT
Background: Chronic liver disease (CLD) presents a significant health burden worldwide, with diverse etiologies contributing to its pathogenesis. Recent research has implicated gut microbiota dysbiosis as the potential driver in progression and exacerbation of CLD. Understanding intricate interplay among gut microbiota composition and liver health is critical for developing targeted therapeutic interventions.
Aim: Our research intended to elucidate effect of gut microbiota dysbiosis on pathogenesis and progression of chronic liver disease through comprehensive investigation and analysis.
Methods: A combination of clinical observations, animal models, and molecular analyses was employed to investigate association among gut microbiota dysbiosis and chronic liver disease. Fecal microbiota profiling, metagenomic sequencing, and host immune response assessments were conducted to delineate the mechanisms underlying the observed effects.
Results: Our findings revealed significant alterations in gut microbiota configuration and functionality in individuals with chronic liver disease compared to healthy controls. Dysbiotic gut microbiota exhibited a pro-inflammatory profile and perturbed metabolic functions, exacerbating liver inflammation and fibrosis progression in animal models. Furthermore, dysbiosis-induced alterations in gut permeability and bacterial translocation were implicated in the exacerbation of liver damage.
Conclusion: The present study underscores the critical role of gut microbiota dysbiosis in driving pathogenesis and progression of chronic liver disease. Targeted interventions intended at modulating gut microbiota composition and restoring intestinal barrier function hold promise for mitigating liver disease severity and improving patient outcomes.
Keywords: Gut microbiota dysbiosis, Chronic liver disease, Pathogenesis, Progression, Inflammation, Fibrosis, Intestinal barrier, Metagenomics, Therapeutic interventions.