Febuaray 2024
DNA content and clinicopathological features aid in distinguishing ameloblastic carcinoma from ameloblastoma
1Dr faiz Muhammad Khoso, 2Dr. Zobia Nissa Memon, 3Dr. Shahzaman Memon, 4Dr Farwa Rubab, 5Dr Qura tul ain Manzoor, 6Dr Muhammad Salman Rashid, 7Khurram Shahzad, 8Kashif Lodhi
1Assistant Professor, Dept: of Oral Pathology, Muhammad Dental College, Ibn-e-Sina University, Mirpurkhas.
2Senior Lecturer, Oral Pathology Department, Isra Dental College, Isra University, Hyderabad
3Assistant Professor, Department of Oral Pathology, Muhammad Dental College, Ibn-e-Sina University Mirpurkhas,
4Senior Registrar Oral & Maxillofacial Surgery, Rashid Latif Medical & Dental College, Lahore
5Senior Registrar Operative Dentistry Rashid Latif Dental College Lahore,
6Assistant Professor Avicenna Dental College Lahore,
7HIESS, Hamdard University, Karachi, Pakistan,
8Department of Agricultural, Food and Environmental Sciences. Università Politécnica delle Marche Via Brecce Bianche 10, 60131 Ancona (AN) Italy,
ABSTRACT
Background: The distinction between ameloblastic carcinoma (AC) and ameloblastoma is crucial for accurate diagnosis and treatment planning. DNA content and clinicopathological features have been recognized as potential indicators to differentiate these two odontogenic neoplasms.
Aim: This study aimed to investigate the utility of DNA content and clinicopathological features in distinguishing ameloblastic carcinoma from ameloblastoma, providing valuable insights for improved diagnostic accuracy and patient management.
Methods: Archival samples of confirmed cases of ameloblastic carcinoma and ameloblastoma were retrospectively analyzed. DNA content was assessed through advanced techniques, and clinicopathological features were meticulously examined. Statistical analyses were employed to identify significant differences between the two groups.
Results: The DNA content analysis revealed distinct patterns between ameloblastic carcinoma and ameloblastoma cases. Additionally, clinicopathological features such as cellular atypia, mitotic activity, and invasion were significantly more pronounced in ameloblastic carcinoma. These findings collectively contribute to a reliable differentiation between the two entities.
Conclusion: The integration of DNA content analysis and clinicopathological features proves to be a robust approach in distinguishing ameloblastic carcinoma from ameloblastoma. This comprehensive diagnostic strategy enhances accuracy and facilitates timely and appropriate clinical interventions, thereby improving patient outcomes.
Keywords: Ameloblastic carcinoma, ameloblastoma, DNA content, clinicopathological features, diagnostic accuracy, differentiation, odontogenic neoplasms.