Abstract
OLP, a chronic immunologic mucocutaneous inflammatory disease, impacts the oral mucosa and affects approximately 0.2-3% of the population. Vitamin B12, or cobalamin, is a crucial micronutrient that plays a significant role in maintaining nerve tissue health, brain function, and the synthesis of red blood cells. Studies indicate that OLP is a localized autoimmune disease caused by T-cell dysfunction.
Objective: To establish the correlation between Lichen Planus and Vitamin B12 insufficiency.
Material and Methods: The study involved patients who met inclusion criteria and visited Abbasi Shaheed Hospital, with informed consent obtained after explaining the procedure, risks, and benefits. The patients were sent for serum B12 level evaluation, comparing healthy individuals (control group) to lichen planus patients (case group). Data was collected and electronically used for research purposes.
Results: The mean age in the case group was 42.35±7.78 years, while in the control group, it was 43.97±8.10 years. In terms of gender distribution, 32(49.2%) were male and 33(50.8%) were female in the case group, whereas 40 ( 61.5%) were male and 25 (38.5%) were female in the control group. The rate of B-12 deficiency was 4 times more likely in cases compared to controls, with an odds ratio of 4.062 C.I (1.50——10.99)]and a highly significant P value of 0.004.
Conclusion: A significant association was found between Lichen Planus and Vitamin B12 deficiency, but more studies with larger sample sizes and parameters are needed to validate the findings.
Keywords: lichen planus . Vit b12, correlation, prevalence