NOVEMBER 2023
Understanding Regional Disparities in Pediatric Severe Sepsis: A Multinational Investigation into Prevalence, Prognosis, and Treatment Strategies
1Dr. Javid Iqbal, 2Dr Muhammad Waqar, 3Dr Alisha Shaukat, 4Dr Saleem Ahmed, 5Dr. Zarmast Khan, 6Khurram Shahzad, 7Kashif Lodhi
1Registrar Paediatrics Department, Khyber Teaching Hospital, Peshawar, jvdiqballkmc241@gmail.com 2Paediatrics Department Lady Reading Hospital Peshawar 3Senior Demonstrator, Department of Community Medicine, Islam Medical and Dental College Sialkot
4Assistant Professor Department of Community Medicine, University College of Medicine and Dentistry, The University of Lahore 5Associate Professor Paediatrics, Niazi Medical and Dental College Sargodha 6HIESS, Hamdard University, Karachi, Pakistan. 7Department of Agricultural, Food and Environmental Sciences. Università Politécnica delle Marche Via Brecce Bianche 10, 60131 Ancona (AN) Italy.
ABSTRACT:
Background: Pediatric severe sepsis is a critical condition with significant morbidity and mortality rates. Disparities in its prevalence, prognosis, and treatment strategies across different regions have been noted, but comprehensive nationwide investigations are lacking.
Aim: This study aimed to comprehensively understand regional differences in the prevalence, prognosis, and treatment strategies of pediatric severe sepsis across the nation.
Methods: A nationwide retrospective analysis was conducted, utilizing data from pediatric healthcare facilities across various regions. Demographic information, clinical characteristics, treatment modalities, and outcomes were collected and analyzed.
Results: Analysis revealed significant regional disparities in the prevalence of pediatric severe sepsis, with varying rates observed across different geographical areas. Prognosis also differed, with disparities noted in mortality rates and long-term outcomes among pediatric sepsis patients from different regions. Furthermore, variations were observed in the utilization of treatment strategies, including antibiotic regimens, fluid resuscitation protocols, and supportive care measures.
Conclusion: This nationwide investigation highlights the existence of significant regional disparities in the prevalence, prognosis, and treatment strategies of pediatric severe sepsis. Understanding these differences is crucial for developing targeted interventions aimed at reducing morbidity and mortality rates associated with pediatric severe sepsis across the nation.
Keywords: Pediatric severe sepsis, regional disparities, nationwide investigation, prevalence, prognosis, treatment strategies.