ABSTRACT
Gynecology clinics often see endometrial carcinoma. The 6th most prevalent female cancer. Postmenopausal women account for almost 75% of endometrial cancer cases. Asian women have a lifetime risk of uterine cancer of 1 in 224. Reports vary on its prevalence in pre- and perimenopausal women. This study compared endometrial cancer rates in pre-, peri-, and post-menopausal women. Obstetrics & Gynecology Department, MCH Center, Pakistan Institute of Medical Sciences, Islamabad conducted this cross-sectional study. The sample size was estimated at 210 with 16.3% endometrial malignancies, 95% confidence, and 5% alpha. The sample was stratified by age: premenopause (30–40 years) (n=70), perimenopause (41–55 years) (n=70), and postmenopause (>55 years). The study took 6 months, January–June 2023. We took written informed consent during enrolling. We enrolled women in these age groups with endometrial carcinoma suspicions. Patients were classified as malignant or not after a thorough diagnosis. In SPSS version 22.0, descriptive and inferential statistics were used to compare baseline characteristics and endometrial cancer by age group. The mean age of responders was 45.9 years, ranging from 31 to 78. We found endometrial cancer in 45 (21.5%) of 210 study cases. This study found cancer rates of 8.0% premenopausal, 15.0% perimenopausal, and 19.0% postmenopausal. This hospital-based study demonstrated endometrial cancer rates vary by age group: pre, peri, and postmenopausal. Diagnostics and treatment should be streamlined by age.
Keywords; Women, menopause, endometrial cancer, pre menopause