ABSTRACT
Background: Endometrial carcinoma (EC) remains a significant health concern globally, with early detection crucial for optimal patient outcomes. Conventional diagnostic methods often face challenges in detecting EC at its incipient stages, prompting the exploration of novel biomarkers and imaging techniques. This study aimed to investigate such innovative approaches for initial exposure and accurate diagnosis of EC.
Aim: The primary goal of the study was to explore novel biomarkers and imaging techniques to improve the early detection and precise diagnosis of endometrial carcinoma, thereby improving patient prognosis and treatment outcomes.
Methods: This study employed a multidisciplinary approach, combining molecular biology, imaging technology, and clinical pathology. Ninety patients presenting with suspected EC were enrolled between January  2023 and January 2024. Blood samples were collected for biomarker analysis, while imaging modalities including MRI, ultrasound, and PET-CT scans were utilized for diagnostic evaluation. Histopathological analysis served as the gold standard for diagnosis, with correlations drawn between biomarker expression, imaging findings, and pathological characteristics.
Results: Biomarker analysis revealed promising candidates for EC detection, including elevated levels of specific proteins and microRNAs. Imaging techniques demonstrated improved sensitivity and specificity in detecting early-stage EC lesions compared to traditional methods. MRI, in particular, showed high accuracy in identifying subtle abnormalities within the endometrium. PET-CT scans provided valuable information on metabolic activity and potential metastatic spread. Histopathological examination confirmed the presence of EC in a subset of patients, validating the efficacy of the novel biomarkers and imaging approaches.
Conclusion: The results of the research highlight potential of novel biomarkers and imaging techniques in the early detection and accurate diagnosis of endometrial carcinoma. Integrating molecular and imaging modalities into routine clinical practice could significantly improve the management of EC by facilitating timely interventions and personalized treatment strategies. More research is warranted to authorize those results in larger cohorts and to discover their utility in longitudinal monitoring and therapeutic response assessment.
Keywords: Endometrial carcinoma, Biomarkers, Imaging techniques, Early detection, Diagnosis, Multidisciplinary approach.