May 2024
Dose-Response effect of Garcinia Cambogia extracts on Blood Urea Nitrogen (BUN) and Serum Creatinine levels among Alloxan Induced Diabetic Rats
1Dr Majid Ali Hingoro, 2Dr Jawad Mumtaz Sodhar, 3Dr Shumaila Shaikh, 4Dr Sadia Tabbassum, 5Dr. Umair Azmat, 6Dr Umair Ali Soomro, 7Mehwish Jaweed, 8Prof. Dr Kashif Rasheed Shaikh, 9Prof Dr Muhammad Atif Ata
1Associate Professor, Department of Pharmacology, Mohi-ud-Din Islamic Medical College, Mirpur AJK, Pakistan
2Associate Professor, Department of Pharmacology, Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan
3Associate Professor, Department of Biochemistry, Khairpur Medical College, Khairpur, Sindh, Pakistan
4Associate Professor, Department of Biochemistry, Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan
5Demonstrator, Department of Pathology, Shahida Islam Medical and Dental College, Lodhran, Pakistan
6Associate Professor, Department of Pathology, Indus Medical College Tando Muhammad Khan, Sindh, Pakistan
7Lecturer, Department of Management sciences, SZABIST University Hyderabad
8Department of Pharmacology, Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan
9Department of Biochemistry, Suleman Roshan Medical College, Tando Adam, Sindh, Pakistan
Correspondence
Prof Dr Kashif Rasheed Shaikh, Suleman Roshan Medical College,Tando Adam, Sindh, Pakistan
Abstract
Introduction As a possible medication for Diabetes Mellitus (DM) and its consequences, the natural supplement garcinia cambogia shows promise. In this respect, the goal of the current study is to examine the possible impacts of various Garcinia cambogia (GC) dosages on the levels of serum creatinine (SC) and blood urea nitrogen (BUN) in Alloxan-induced diabetic rats.
Methodology Rats were kept in stainless steel cages with sawdust bedding, stainless steel feed containers, and plastic drinks with stainless nozzles. The light/dark cycle was kept at 12-hour intervals, and they were given access to lab food and water at will. The NIH Guide for the Care and Use of Laboratory Animals was followed for housing and handling the animals.
Results The treated experimental groups, group C (19.28±1.68 mg/dl), group D (18.48±1.54 mg/dl), and group E (14.27±2.43 mg/dl), all showed a notable decrease in blood urea nitrogen (BUN) levels. Contrastingly, the positive control group B showed a considerably higher BUN level of 23.63±3.04 mg/ml compared to the negative control group A’s BUN level of 8.43±0.69 mg/ml. The statistical significance of this difference was unusually high (F-value = 158.3 and P = 0.0001).
Conclusion The results show that the GcE-treated experimental groups (C, D, and E) had significantly lower blood urea nitrogen (BUN) levels than the positive control group (B) that was not given any treatment. The study also shows that these GcE-treated groups had significantly lower serum creatinine (SCr) levels, which supports the beneficial effects of GcE on renal function even further.
Keywords Diabetes Mellitus, Serum Creatinine, Blood Urea Nitrogen