ABSTRACT:
Background: Thrombotic Microangiopathies (TMAs) represent a spectrum of disorders characterized by microvascular thrombosis and organ dysfunction. Although commonly associated with various renal pathologies, their incidence specifically in postnatal acute kidney injury (AKI) patients remains less explored. This study aimed to investigate the prevalence of TMAs among postnatal AKI patients presenting to the Nephrology Division of Khyber Teaching Hospital in Peshawar.
Aim: The primary aim of this study was to determine the incidence of Thrombotic Microangiopathies (TMAs) in postnatal acute kidney injury (AKI) patients at the Nephrology Division of Khyber Teaching Hospital, Peshawar.
Methods: A retrospective analysis was conducted on medical records of 100 postnatal AKI patients admitted to the Nephrology Division of Khyber Teaching Hospital, Peshawar, over a period of seven months from January 2023 to July 2023. Patients’ demographics, clinical presentations, laboratory findings, and renal biopsy reports were reviewed to identify cases of TMAs.
Results: Among the 100 postnatal AKI patients included in the study, 18% were diagnosed with Thrombotic Microangiopathies (TMAs) based on renal biopsy findings. Common presenting symptoms among TMA-positive patients included hematuria, proteinuria, and hypertension. Laboratory investigations revealed elevated levels of serum creatinine and decreased platelet counts in the TMA- positive group compared to TMA-negative patients.
Conclusion: This study highlights a significant incidence of Thrombotic Microangiopathies (TMAs) among postnatal AKI patients presenting to the Nephrology Division of Khyber Teaching Hospital, Peshawar. Early recognition and management of TMAs are crucial to prevent further renal damage and improve patient outcomes.
Keywords: Thrombotic Microangiopathies (TMAs), acute kidney injury (AKI), postnatal, incidence, renal biopsy, Khyber Teaching Hospital, Peshawar.